Knapp, Spencer

Project Description

Organic synthesis:

  • Total synthesis of natural products
  • New synthetic methods
  • New drug delivery systems
  • New anti-malaria and anti-inflammatory drug candidates
  • Enzyme inhibitors, models, and mechanism


GPA: 3.5, chemistry major preferred

Course Experience:

  • Organic chemistry – 1 year
  • Organic lab – 1 or 2 semesters preferred

Current Undergraduate Researchers

  • Soomin Jin
  • Evan Lenkeit
  • Alex Mozsolits

Recent Publications with Undergraduate Co-authors (in bold)

Spencer Knapp, Richard C. Huhn, and Benjamin Amorelli. “Thionation: GlcNAc-Thiazoline Triacetate {(3aR,5R,6S,7R,7aR)-5-Acetoxymethyl-6,7-diacetoxy-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2- d]thiazole}” Organic Syntheses 2007, 84, 68.

Spencer Knapp, Mohannad Abdo, Richard C. Huhn, Thomas J. Emge, Eun Ju Kim, and John A. Hanover. “Tautomeric Modifications of GlcNAc-Thiazoline” Org. Lett. 2007, 9, 2321.

Spencer Knapp, David Fash, Mohannad Abdo, Thomas J. Emge, and Paul R. Rablen. “GlcNAc-Thiazoline Conformations” Bioorg. Med. Chem. 2009, 17, 1831

Jian Liu, Zheng Wang, Aaron Levin, Thomas J. Emge, Paul R. Rablen, David M. Floyd, and Spencer Knapp. “N-Methylimidazole Promotes the Reaction of Homophthalic Anhydride with Imines” J. Org. Chem. 2014, 79, 7593.

Julia Hong, Zheng Wang, Aaron Levin, Thomas J. Emge, David M. Floyd, and Spencer Knapp. “Dimerization and Comments on the Reactivity of Homophthalic Anhydride” Tetrahedron Lett. 2015, 56, 3001.

Daniel Polyak, Ngan Phung, Robert Barrows, Thomas J. Emge, and Spencer Knapp. “Stereochemistry and Reactivity of the HPA-imine Mannich Intermediate” Tetrahedron Lett. 2017, 58, 3879.

Claire Jarvis, Neyra Jemal, Spencer Knapp, and Daniel Seidel. “Formal [4+2] Cycloaddition of Imines with Alkoxyisocoumarins” Org. Biomol. Chem. 2018, 16, 4231.

Robert D. Barrows, Jared T. Hammill, Michael C. Tran, Mofolusho O. Falade, Amy L. Rice, Christopher W. Davis, Thomas J. Emge, Paul R. Rablen, R. Kiplin Guy, and Spencer Knapp. “Evaluation of 1,1-Cyclopropylidene as a Thioether Isostere in the 4-Thio-thienopyrimidine (TTP) Series of Antimalarials.” Bioorg. Med. Chem. 2020, 28, 115758.