Nondestructive Characterization of Stem Cell Neurogenesis by a Magneto-Plasmonic Nanomaterial-Based Exosomal miRNA Detection

KiBum Article Pic Nondestructive Characterization of Stem Celltif To this end, scientists from Prof. KiBum Lee’s Lab (Jin-Ho Lee et al.) have recently developed a multifunctional magneto-plasmonic nanorod (NR)-based detection platform to address the limitations associated with the current destructive characterization methods of stem cell neurogenesis. The developed nondestructive, selective, and sensitive detection platform has (i) an immunomagnetic active component for exosome isolation and (ii) a plasmonic/metal-enhanced fluorescence component for sensitive exosomal miRNA detection to characterize stem cell differentiation. In a proof-of-concept demonstration, the multifunctional magneto-plasmonic NR successfully detected the expression level of miRNA-124 and characterized neurogenesis of human-induced pluripotent stem cell-derived neural stem cells in a nondestructive and efficient manner. Furthermore, we demonstrated the versatility and feasibility of our multifunctional magneto-plasmonic NRs by characterizing a heterogeneous population of neural cells in an ex vivo rodent model. Collectively, multifunctional magneto-plasmonic NR-based exosomal miRNA detection platform has a great potential to investigate the function of cell-cell interactions and intrinsic cellular regulators for controlling stem cell differentiation.

This work was published recently in ACS NANO (Lee, J. -H. et al. 2019, In Press), DOI:10.1021/acsnano.9b01875.

This work was highlighted in various media sources:

Nanotechnology could boost stem cell transplantation research. News-Medical covers a Rutgers-led study on new nanotechnology for characterizing stem cells, quoting KiBum Lee (SAS).

Rutger’s Nanotechnology Research Might Help with Alzheimer’s, Parkinson’s and Other Diseases. BioSpace covers a Rutgers-led study on new nanotechnology for characterizing stem cells, quoting KiBum Lee (SAS).

New nanotechnology platform could aid stem cell transplantation research. Nanowerk covers a Rutgers-led study on new nanotechnology for characterizing stem cells, quoting KiBum Lee (SAS).

Nanotechnology could aid stem cell transplantation research. Nano magazine covers a Rutgers-led study on new nanotechnology for characterizing stem cells, quoting KiBum Lee (SAS).

Rutgers’ Nanotechnology Research Might Help with Alzheimer’s, Parkinson’s and Other Diseases. PharmaLive covers a Rutgers-led study on new nanotechnology for characterizing stem cells, quoting KiBum Lee (SAS).

New nanotechnology could aid stem cell transplantation research. Science Bulletin covers a Rutgers-led study on new nanotechnology for characterizing stem cells, quoting KiBum Lee (SAS).

Nanotechnology platform could improve stem cell transplantation. Drug Target Review covers a Rutgers-led study on new nanotechnology for characterizing stem cells, quoting KiBum Lee (SAS).

New technology could aid stem cell transplantation research. NJBIZ covers a Rutgers-led study on new nanotechnology for characterizing stem cells, quoting KiBum Lee (SAS).