Advancing Organoid Research Using Bionanotechnology Approaches
Stem cells are characterized by a unique ability to self-renew and differentiate and have revolutionized modern biological sciences and medical researches with unique approaches for understanding developmental processes and disease modeling. With recent advances in 3D cell culture technology, stem cells are allowed to reside in culture environments emancipating their intrinsic self-organizing properties and form into “organoids” resembling structural as well as functional characteristics of organs [Figure 1]. To advance organoid development, diverse advanced material and engineering techniques have been incorporated into conventional organoid culture methods [Figure 1]. Despite the wide use of organoids and the recent surge of research activity in this field, a comprehensive review covering engineering extracellular matrices to support organoid culture for developmental studies, 3D organ-level biology, and bioengineering-based disease modeling is lacking.